CONSIDERATIONS TO KNOW ABOUT PKRRATING

The interfacial residues are really conserved among eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements show which the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations assist a model where activating RNA serves as a scaffold to bind check here several PKR monomers, rising the

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